Aims: To evaluate and compare the effectivenessof two concentrations of topical clonazepam solution in improving symptoms ofburning mouth syndrome (BMS). Methods:A retrospective chart review was conducted of patients diagnosed with BMS andmanaged with topical clonazepam solution between 2008 and 2015. A 0.5-mg/mLsolution was prescribed until 2012, when this was changed to a 0.1 mg/mLsolution. Patients were instructed to swish with 5 mL for 5 minutes and spittwo to four times daily. The efficacies of the two concentrations were comparedusing patient-reported outcome measures at the first follow-up, including thereported percentage of improvement in burning symptoms and the change inburning severity from baseline ranked on an 11-point numeric rating scale(NRS). Response to treatment was compared between the two concentrations usingWilcoxon rank sum test. Results: Atotal of 57 subjects were included, 32 in the 0.1-mg/mL cohort and 25 in the0.5-mg/mL cohort, and evaluated at a median follow-up of 7 weeks. The medianoverall percentage improvement was 32.5% in the 0.1-mg/mL cohort and 75% in the0.5-mg/mL cohort. The median reduction in NRS score was 0.5 points in the0.1-mg/mL cohort and 6 points in the 0.5-mg/mL cohort. The use of eitheroutcome measure revealed that the response to treatment with the 0.5-mg/mLsolution was superior to that of the 0.1 mg/mL solution (P < .01). Conclusion: These findings suggest thata 0.5-mg/mL topical clonazepam solution is effective in the management of BMS.Future randomized clinical trials are warranted.
Curved root canalsare within the complex anatomic range of the root canal system and a possiblereason for failure in the preparation of the root canals during root canaltreatment. The introduction of NiTi files was a milestone for accessingdifficult root canal anatomy. Lately, manufacturers have focused on thedevelopment of single file NiTi systems. The comparison of these rotary singlefile systems to the established full sequence NiTi systems, particularly withregard to their performance in curved canals, is being researched thoroughly.The main objective of this case report is to show the clinical performance ofthe rotary NiTi single file system F6 SkyTaper (Komet, Lemgo, Germany) inseverely curved root canals.
“Fundamentals of Implant Dentistry” provides a concise yetcomprehensive look at the basic background and science of implantology. Sincethe concept of osseointegration was introduced to the dental community morethan 35 years ago by Professor P-I Brånemark, significant improvements havebeen achieved in patient evaluation, methods used to enhance the bone and softtissues of potential implant sites, and surgical techniques to prepare theosteotomy sites and place the implants.
